Reggie Bush won’t play against the Arizona Cardinals today.

The Detroit Lions running back did not practice all week due to an ankle sprain that he tweaked a week ago in the win over the Dolphins. Bush worked out on the sidelines with trainers on Thursday and Friday while his teammates prepared for today’s game. Bush also missed games in Week 6 and Week 8.

The Lions won’t have all their tight ends back. Brandon Pettigrew (foot) is inactive. 

Joe Fauria and Eric Ebron return to action. Fauria has missed six games with an ankle sprain, while Ebron sat out three games with a hamstring. Kellen Davis is also active.

Defensive tackle Nick Fairley and right guard Larry Warford, both with knee injuries, were listed as out on Friday’s injury report.

C.J. Mosley will start for Fairley while rookie Travis Swanson will start at right guard.

Other inactives include: Wide receiver Ryan Broyles, defensive end Larry Webster and quarterback Kellen Moore.

Kickoff is 4:25 p.m. The game will air on FOX.